Endocrine Abstracts

Introduction: PTHrP (Parathyroid hormone-related protein) is known to enhance beta cell function and proliferation. PTH levels predict myocardial and coronary heart disease in non-diabetic patients with normal calcium levels and no kidney failure. We aimed at determining in type 2 diabetes patients without kydney failure the relationship between serum levels of 1-84 parathormone (PTH1-84), obesity, HOMA insulin-sensitivity or beta-cells function (HOMA-B), but also between PTH1...

Objective: Increasing evidence suggests a role for mineral metabolism in cardio-vascular disease risk. We aimed at determining in type 2 diabetes patients the relationship between serum levels of 1–84 parathormone (PTH1–84), 25-hydroxy-vitamin D (25(OH)D) or calcium and the glycated hemoglobin (HbA1c), insulin sensitivity or β-cells function, but also the relationship between these factors and coronary arterial disease confirmed by myocardial scintigraphy.<p...

Objective: Matrix γ-carboxyglutamate (Gla) protein (MGP) is a marker of athero-sclerosis reflecting the degree of inhibition of ongoing calcification processes in the vascular wall. Osteoprotegerin (OPG) and adiponectin (ADP) exerts anti-inflammatory and anti-atherosclerotic effects. We aimed at determining in type 2 diabetes patients the relationship between serum MGP, OPG, ADP levels and the HbA1c, HOMA insulin-sensitivity or B-cell function.Resea...

Background: Patients with an insulinoma are at variable risk of severe hypoglycemia due to wide ranges of both tumoral insulin secretion and peripheral tissue sensitivity to chronic hyperinsulinaemia.Objectives: In this study we investigated the clinical, biological and tumoral characteristics of a large series of patients with immunohistochemically confirmed insulinoma and we assessed both insulin sensitivity and beta-cell function in fasting steady-sta...